Histological examination of endometrial biopsy
To accurately diagnose and determine the stage of the pathological process, doctors often prescribe a histological examination of the endometrium. Samples of the mucous membrane of the uterine wall are examined in the laboratory under microscopes with multiple magnifications to assess the structure of the tissue and identify possible signs of gynecological pathology.
In the Dobrobut MC clinic, diagnostics is carried out after an aspiration or a pipelle biopsy of the endometrium - modern low-traumatic types of biomaterial sampling. The price of a histological examination in Kyiv depends on the urgency of the implementation, the method of analysis, additional services.
What does a histological examination show?
- hyperplasia (growth) of the endometrium;
- inflammatory infiltration of the endometrium;
- an increase in the number and violation of the structure of the uterine glands;
- atypical cells;
- fibrous processes in the wall of the uterus;
- violation of the structure of the blood vessels of the endometrium.
With insufficient information content of the classical analysis, specific markers are studied: estrogen and progesterone receptors, markers of lymphocytes, and plasma cells. The price of a histological examination with immunohistochemistry will be higher, but the diagnostic results are more accurate.
Indications for analysis
- endometrial polyps;
- endometrial cancer;
- chronic endometritis;
- endometrial hyperplasia;
- insufficiency of the second phase of the menstrual cycle;
- endometriosis;
- intermenstrual bleeding and uterine bleeding in women during menopause.
Diagnostics are also used to evaluate the effectiveness of conservative treatment and in preparation for surgical interventions. For patients at high risk of developing malignant tumors, endometrial histology may be prescribed as a screening method to exclude or early detection of a tumor process.
Histological examination of the endometrial pipelle biopsy is a mandatory diagnostic step for women with infertility, miscarriage, as well as in the period of preparation for the IVF protocol in Ukraine.
How is the procedure carried out
The cost of histological examination in Kyiv is usually indicated taking into account the sampling of biomaterial. For women in menopause, the procedure can be performed on any day, and for patients of reproductive age, a biopsy is performed on certain days of the cycle, taking into account complaints and the alleged disease.
The study consists of several stages:
- Primary doctor's appointments and a standard set of diagnostic methods are used in gynecology.
- Selection of the date of the biopsy and the issuance of recommendations to the patient in preparation for the procedure.
- The sampling of the epithelium from the surface of the endometrium using a Pipelle probe.
- Placement of tissue samples in a fixative solution and delivery to the laboratory.
- Preparation of histological preparations from biopsy specimens and study of their structure under a microscope.
- Issuance of an expert opinion describing the norm and indicating all the identified signs of pathology.
The timing of histological diagnosis of the endometrium is an average of 7-10 working days. In some cases, it is possible to conduct an urgent analysis.
Before taking material for laboratory diagnostics, a woman needs to consult a gynecologist, take a vaginal smear, and do an ultrasound of the pelvic organs. At the appointment, the doctor will tell you how much the histological examination costs and how the procedure will be carried out. The entire set of tests can be quickly done at the Dobrobut MC clinic in Kyiv. Our doctors are highly experienced in performing invasive diagnostics and use modern equipment to get accurate results and make a quick diagnosis.
An appointment for a consultation with a doctor at the Dobrobut MC clinic is carried out by phone or through a request in the feedback form.
Bibliography
- Жураківський, Віктор Миколайович, Людмила Володимирівна Пахаренко, and Ірина Омелянівна Басюга. Морфологічні зміни ендометрію у жінок з фіброміомою матки. Problems and tasks of modernity and approaches to their solution 8 (2021): 103.
- Mielikhova, T. V., et al. Оптимізація діагностичних досліджень у пацієнток із аденоміозом та/або гіперпластичними процесами ендометрія. Reproductive Endocrinology 58 (2021): 34-39.
- Günakan E, Atak Z, Albayrak M, Kurban Y, Şimşek GG. Endometrial histopathology results and evaluation of endometrial cancer risk in geriatric women. Prz Menopauzalny. 2018;17(1):18-21.
- Malinowski J, Wilczyński M, Depta A, Malinowski A. Diagnostic value of histopathological examination results obtained during screening of patients with diagnosed atypical hyperplasia. Prz Menopauzalny. 2018;17(4):144-148.
- Inal ZO, Inal HA, Kucukosmanoglu I, Kucukkendirci H. Assessment of Endometrial Sampling and Histopathological Results: Analysis of 4,247 Cases. Eurasian J Med. 2017;49(1):44-47.
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